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KMID : 0381219890210040384
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Journal of RIMSK
1989 Volume.21 No. 4 p.384 ~ p.389
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An Experimental Study on Auto- and Allograft of the Peritoneum in Rabbits
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Abstract
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For a long time, skin graft has been a traditional method of choice for treating mucosal and conjuctival defects. And the result of skin graft, however, has never been satisfactory, because of its poor hygiene with hair growth, secretion and its contractive quality.
So, we have done an experiment, in which a piece of rabbit peritoneum, as a substitute for skin graft, was grafted to the subcutaneous tissue on the back of rabbits. 20 rabbits were divided into 2 groups; autograft and allograft treated with cyclosporin, a newly developed immunosupressive agent.
Gross and microscopic appearances were examined at postoperative 1, 2, 3 and 4 week.
The results were as follows;
1) In autograft group, all grafted peritoneum survived through the whole observation period of 4 weeks.
2) In allograft group, treated with cyclosporin, grafted peritoneum survived in nine rabbits among ten (90%), through the whole observation period of 4 weeks.
3) In both groups, all survived pertoneum showed no differences in gross appearance from that of normal peritoneum.
4) In both groups, all survived peritoneum microscopically showed maintenace of mesothelial layer and proliferation of fibrous tissue. Such appearance is more definite in autograft group.
5) In conclusion of above results in heterotopic graft, rabbit peritoneum was proved to survive for at least 4 weeks both after autograft and allograft treated with cyclosporin. Therefore, a possibility is postulated that the peritoneum is thought to be a useful substitute for mucosal and conjunctival defects.
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